Mhairi Copland Selected Research

7- cyano- 2,3,4,5- tetrahydro- 1- (1H- imidazol- 4- ylmethyl)- 3- (phenylmethyl)- 4- (2- thienylsulfonyl)- 1H- 1,4- benzodiazepine (BMS 214662)

11/2009	BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta.
3/2008	BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors.

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Mhairi Copland Research Topics

Disease

19	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 01/2006
7	Neoplasms (Cancer) 04/2022 - 03/2008
4	Blast Crisis (Blast Phase) 02/2022 - 03/2008
4	Leukemia 01/2021 - 02/2007
2	Carcinogenesis 04/2016 - 01/2013
2	Myeloid Leukemia (Leukemia, Myelocytic) 01/2015 - 01/2005
1	Bronchiolitis Obliterans Syndrome 04/2022
1	Cardiomyopathies (Cardiomyopathy) 02/2022
1	Philadelphia Chromosome 02/2022
1	Intracranial Sinus Thrombosis (Sinus Thrombosis) 02/2022
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2021
1	Residual Neoplasm 09/2021
1	Hematologic Neoplasms (Hematological Malignancy) 01/2021
1	Peripheral Arterial Occlusive Disease 1 07/2017
1	Carcinoma (Carcinomatosis) 08/2013
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 03/2013
1	Genomic Instability 12/2012
1	Chromosome Aberrations (Chromosome Abnormalities) 12/2012
1	Invasive Fungal Infections 02/2005
1	Neutropenia 01/2005

Drug/Important Bio-Agent (IBA)

8	Tyrosine Kinase InhibitorsIBA 02/2022 - 03/2008
8	Imatinib Mesylate (Gleevec)FDA Link 07/2017 - 01/2005
6	bcr-abl Fusion ProteinsIBA 01/2020 - 02/2007
5	Phosphotransferases (Kinase)IBA 09/2014 - 01/2006
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2011
3	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 02/2022 - 01/2005
2	Cytarabine (Cytosar-U)FDA LinkGeneric 02/2022 - 12/2021
2	7- cyano- 2,3,4,5- tetrahydro- 1- (1H- imidazol- 4- ylmethyl)- 3- (phenylmethyl)- 4- (2- thienylsulfonyl)- 1H- 1,4- benzodiazepine (BMS 214662)IBA 11/2009 - 03/2008
2	Dasatinib (BMS 354825)FDA Link 12/2008 - 06/2006
1	Monoclonal AntibodiesIBA 04/2022
1	Rituximab (Mabthera)FDA Link 04/2022
1	fludarabineIBA 02/2022
1	ponatinibIBA 02/2022
1	Alanine Transaminase (SGPT)IBA 02/2022
1	Amylases FDA Link 02/2022
1	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 02/2022
1	quizartinibIBA 12/2021
1	AntigensIBA 01/2021
1	VaccinesIBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 04/2016
1	Transcription Factors (Transcription Factor)IBA 09/2014
1	DNA (Deoxyribonucleic Acid)IBA 08/2013
1	Peptides (Polypeptides)IBA 08/2013
1	Phenylalanine (L-Phenylalanine)FDA Link 08/2013
1	Pharmaceutical PreparationsIBA 01/2013
1	Nucleic AcidsIBA 01/2013
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2012
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 06/2011
1	Protein Kinases (Protein Kinase)IBA 11/2009
1	src-Family KinasesIBA 12/2008
1	Farnesyltranstransferase (Farnesyltransferase)IBA 03/2008
1	Peptide Initiation Factors (Initiation Factor)IBA 02/2007
1	MannansIBA 02/2005
1	galactomannanIBA 02/2005
1	ImmunosorbentsIBA 02/2005
1	EnzymesIBA 02/2005
1	Filgrastim (Neupogen)FDA Link 01/2005

Therapy/Procedure

11	Therapeutics 04/2022 - 02/2007
4	Drug Therapy (Chemotherapy) 02/2022 - 03/2008
1	Transplantation 04/2022
1	Salvage Therapy 02/2022
1	Stem Cell Transplantation 05/2008